Determine TB-LAM point-of-care tuberculosis assay predicts poor outcomes in outpatients during their first year of antiretroviral therapy in South Africa.
Andrew D KerkhoffNicky LongleyNicola KellyAnna CrossMonica VogtRobin WoodSabine HermansStephen D LawnThomas S HarrisonPublished in: BMC infectious diseases (2020)
Systematic urine-LAM testing among ART-naïve HIV-positive outpatients with CD4 counts < 100 cells/uL detected TB cases that were missed under routine programme conditions and was highly predictive for subsequent hospitalization and mortality in the first year of ART.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv aids
- mycobacterium tuberculosis
- human immunodeficiency virus
- south africa
- hiv infected patients
- induced apoptosis
- cell cycle arrest
- men who have sex with men
- pulmonary tuberculosis
- high throughput
- cardiovascular events
- clinical practice
- peripheral blood
- clinical trial
- herpes simplex virus
- cell death
- emergency department
- weight loss
- nk cells
- skeletal muscle
- cell proliferation
- pi k akt
- coronary artery disease
- glycemic control
- metabolic syndrome