Impact of C4, C4A and C4B gene copy number variation in the susceptibility, phenotype and progression of systemic lupus erythematosus.

Kaline Medeiros Costa PereiraSandro PerazzioAtila Granado A FariaEloisa Sa MoreiraViviane C SantosMarcelle GreccoNeusa Pereira da SilvaLuis Eduardo Coelho de Andrade

Published in: Advances in rheumatology (London, England) (2019)

This study confirms the association between low C4 GCN and SLE susceptibility, and originally demonstrates an association between low C4A GCN and disease severity.

Keyphrases

copy number
systemic lupus erythematosus
mitochondrial dna
genome wide
disease activity
dna methylation
rheumatoid arthritis
gene expression
transcription factor