MEX3A Impairs DNA Mismatch Repair Signaling and Mediates Acquired Temozolomide Resistance in Glioblastoma.

Tian Gan Yan Wang Manyi Xie Qiang Wang Saisai Zhao Peng Wang Qinyu Shi Xuanchen Qian Faan Miao Zhigang Shen Er Nie

Published in: Cancer research (2022)

A MEX3A/CCR4-NOT/MSH2 axis plays a crucial role in promoting temozolomide resistance, providing new insights into the function of MEX3A and suggesting MEX3A as a potential therapeutic target in therapy-resistant glioblastoma.

Keyphrases

newly diagnosed
dendritic cells
circulating tumor
regulatory t cells
stem cells
immune response
climate change
human health