Longer leukocyte telomere length is associated with myeloid inflammation and increased mortality after transcatheter aortic valve replacement.
Jedrzej HoffmannNoriaki TabataSilvia Mas-PeiroIoakim SpyridopoulosJan-Malte SinningAlexander BerkowitschCarmen Martin-RuizBaravan Al-KassouEva HerrmannStefanie DimmelerAndreas M ZeiherMariuca Vasa-NicoteraPublished in: European heart journal open (2022)
Longer LTL is associated with increased mortality after TAVR. This might be explained by enhanced proliferative capacity of cells resulting in myeloid and systemic inflammation. Our findings suggest that targeting the specific inflammation pathways could present a novel strategy to augment survival in selected patients with degenerative aortic stenosis.
Keyphrases
- transcatheter aortic valve replacement
- aortic stenosis
- aortic valve
- aortic valve replacement
- oxidative stress
- transcatheter aortic valve implantation
- induced apoptosis
- ejection fraction
- dendritic cells
- bone marrow
- acute myeloid leukemia
- left ventricular
- cell cycle arrest
- cancer therapy
- coronary artery disease
- endoplasmic reticulum stress
- heart failure