Antimicrobial activity and mechanism of anti-MRSA of phloroglucinol derivatives.

Xianjing YangXinjiao GaoJiayi OuGong ChenLianbao Ye

Published in: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences (2024)

Acylphloroglucinol derivative A5 showed good anti-MRSA activity, possibly via membrane damage and ROS-mediated oxidative stress mechanism. It deserves further exploration to be a potential lead for the development of new anti-MRSA agent.

Keyphrases

methicillin resistant staphylococcus aureus
oxidative stress
staphylococcus aureus
dna damage
cell death
ischemia reperfusion injury
reactive oxygen species
induced apoptosis
human health
structure activity relationship