Maternal folate genes and aberrant DNA hypermethylation in pediatric acute lymphoblastic leukemia.

Jeremy M SchrawTeresa T YiuPhilip J LupoSpiridon TsavachidisRachel RauMelissa L BondyKaren R RabinLanlan ShenMichael E Scheurer

Published in: PloS one (2018)

Maternal folate metabolic genotype may be associated with DNA methylation patterns in ALL in their offspring. Therefore, the effect of maternal genotypes on ALL susceptibility may act through aberrant promoter methylation, which may contribute to the in utero origins of ALL.

Keyphrases

dna methylation
acute lymphoblastic leukemia
genome wide
birth weight
pregnancy outcomes
gene expression
transcription factor
gestational age
pregnant women
high fat diet
single molecule
allogeneic hematopoietic stem cell transplantation
body mass index
insulin resistance
circulating tumor cells