Discordance of epidermal growth factor receptor mutation between primary lung tumor and paired distant metastases in non-small cell lung cancer: A systematic review and meta-analysis.
Chia Ching LeeYu Yang SoonChar Loo TanWee Yao KohCheng Nang LeongJeremy Chee Seong TeyIvan Weng Keong ThamPublished in: PloS one (2019)
The overall discordance rate in EGFR mutation between primary lung tumor and paired distant metastases in NSCLC is low, although higher discordance rates were observed in bone metastases compared with CNS and lung/pleural metastases. Future studies assessing the impact of EGFR mutation discordance on treatment outcomes are required.