Local IL-17 positive T cells are functionally associated with neutrophil infiltration and their development is regulated by mucosal microenvironment in nasal polyps.
Sifei YuChen CaoQianying LiXueyi WenXuexue GuoQing BaoYutao ZhouLiyue LiXiaoyan YeTianying LiHexin ChenChangyou WuChunwei LiPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2020)
This study determined a functional association of IL-17+ T cells with neutrophils in CRSwNP, and revealed that polyp microenvironment could promote IL-17+ T cell differentiation, suggesting a potential feedback role for IL-17+ T cell development and local neutrophilic inflammation.