Cerebrospinal fluid cfDNA sequencing for classification of central nervous system glioma.

Florian Iser Felix Hinz Dirk C Hoffmann Niklas Grassl Cansu Güngoör Jochen Meyer Laura Dörner Lea Hofmann Vanessa Kelbch Kirsten Göbel Mustafa Ahmed Mahmutoglu Phillipp Vollmuth Areeba Patel Duy Nguyen Leon D Kaulen Iris Mildenberger Katharina Sahm Kendra K Maass Kristian W Pajtler Ganesh M Shankar Markus Weiler Brigitte Wildemann Frank Winkler Andreas von Deimling Michael Platten Wolfgang Wick Felix Sahm Tobias Kessler

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

We developed a targeted sequencing workflow for CSF cfDNA as well as a strategy for interpretation and reporting of sequencing results based on a molecular-guided tumor classification in glioma.

Keyphrases

cerebrospinal fluid
single cell

machine learning
deep learning

cancer therapy
emergency department

adverse drug
drug delivery