Directly observed therapy and risk of unfavourable tuberculosis treatment outcomes among an international cohort of people living with HIV in low- and middle-income countries.

April C PettitCathy A JenkinsMeridith Blevins PeratikosMarcel YotebiengLameck DieroCuong D DoJeremy RossValdilea G VelosoDenise HawerlanderOlivier MarcyBryan E ShepherdLukas FennerTimothy R Sterlingnull null

Published in: Journal of the International AIDS Society (2020)

In this large, international cohort of people living with HIV-associated TB in LMIC who received intensive phase DOT, DOT during the continuation phase of anti-TB therapy was not associated with a decreased odds of unfavourable TB treatment outcomes compared to SAT. Randomized trials evaluating the effect of continuation-phase DOT on TB outcomes among PLHIV are needed.

Keyphrases

mycobacterium tuberculosis
pulmonary tuberculosis
energy transfer
emergency department
bone marrow
hepatitis c virus
hiv aids
adverse drug