IκB kinase ε contributes to the pathogenesis of osteoarthritis by promoting cartilage degradation.

These results suggest that IKKε regulates cartilage degradation through a catabolic response mediated by NF-κB signaling, and is a potential target for OA treatment. Furthermore, BAY-985 may serve a major compound in drugs developed for OA. This article is protected by copyright. All rights reserved.