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Synthesis of CF3-Containing Linear Nitriles from α-(Trifluoromethyl)styrenes.

Sixue XuYupian DengJingjing HeQianding ZengChuan LiuYi ZhangBin ZhuSong Cao
Published in: Organic letters (2021)
Four unprecedented base-catalyzed/mediated nucleophilic additions of TMSCN to α-(trifluoromethyl)styrenes and 2-trifluoromethyl enynes were developed. The reaction proceeded smoothly at room temperature under mild and transition-metal-free conditions without affecting the trifluoromethyl group and afforded the corresponding CF3-containing alkyl, alkynyl, and butadienyl nitriles in moderate to excellent yields in a highly regioselective manner, respectively.
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