Persistent Exhausted T-Cell Immunity after Severe COVID-19: 6-Month Evaluation in a Prospective Observational Study.
Elena Vázquez-AlejoLaura Tarancon-DiezMaria de la Sierra Espinar-BuitragoMiguel GenebatAlba CalderónGuillermo Pérez-CabezaEsmeralda Magro-LopezManuel LealMaria Angeles Muñoz-FernándezPublished in: Journal of clinical medicine (2023)
The immunological activation in the SARS-CoV-2 group during hospitalization is reversed at the follow-up time point. However, the marked exhaustion pattern remains over time. This dysregulation could constitute a risk factor for reinfection and the development of other pathologies. Additionally, high SARS-CoV-2-specific T-cells response levels appear to be associated with infection severity.