Hsa_circ_0000479/Hsa-miR-149-5p/RIG-I, IL-6 Axis: A Potential Novel Pathway to Regulate Immune Response against COVID-19.

Zahra FirooziElham Mohammadisoleimani Abbas ShahiMohammad Mehdi NaghizadehEbrahim MirzaeiAli Ghanbari AsadZahra SalmanpourSeyed Mohamad Javad NouriYaser Mansoori

Published in: The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale (2022)

Upregulation of hsa_circ_0000479, RIG-I, and IL-6, and downregulation of hsa-miR-149-5p, along with correlation studies, indicate that hsa_circ_0000479/hsa-miR-149-5p/RIG-I, IL-6 axis could play a role in regulating the immune response against SARS-CoV-2. However, more studies are needed in this area.

Keyphrases

sars cov
immune response
coronavirus disease
cell proliferation
signaling pathway
dendritic cells
respiratory syndrome coronavirus
case control
risk assessment
inflammatory response
human health