A bronchial gene signature specific for severe COPD that is retained in the nose.

Jos van NijnattenAlen FaizHidde J Haisma Victor Guryev Dirk-Jan SlebosKarin KloosterJorine E Hartman Tessa M KoleDavid F ChoyArindam ChakrabartiMichele GrimbaldestonAdrienne G Randolph Huib A M KerstjensCorry-Anke BrandsmaMaarten van den Berge

Published in: ERJ open research (2023)

, which was retained in the upper airways. This supports the hypothesis that severe COPD, at least partly, comprises a different pathology and supports the potential for biomarker development based on nasal brushes in COPD.

Keyphrases

chronic obstructive pulmonary disease
lung function
cystic fibrosis
early onset
copy number
genome wide
gene expression
dna methylation
risk assessment
human health
transcription factor
genome wide identification