Dickkopf-1 directs periosteal bone formation in two murine models of inflammatory arthritis.

A T Shaw J YanS A KuhstossJulia Forgan-Farnam Charles Ellen M Gravallese

Published in: Scandinavian journal of rheumatology (2022)

DKK1 is a regulator of periosteal bone formation in inflammatory arthritis. Thus, regulation of DKK1 may be considered as a therapeutic approach in inflammatory diseases in which patients suffer from excessive periosteal bone formation, such as spondyloarthritis.

Keyphrases

end stage renal disease
oxidative stress
rheumatoid arthritis
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
transcription factor
disease activity
physical activity
weight loss