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Dickkopf-1 directs periosteal bone formation in two murine models of inflammatory arthritis.

A T ShawJ YanS A KuhstossJulia Forgan-Farnam CharlesEllen M Gravallese
Published in: Scandinavian journal of rheumatology (2022)
DKK1 is a regulator of periosteal bone formation in inflammatory arthritis. Thus, regulation of DKK1 may be considered as a therapeutic approach in inflammatory diseases in which patients suffer from excessive periosteal bone formation, such as spondyloarthritis.
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