Epithelial ovarian cancer and brain metastases: might the BRCA status, PARP inhibitor administration, and surgical treatment impact the survival?
Carolina Maria SassuClaudia MarchettiGiorgia RussoAngelo MinucciSerena Maria BocciaAlberto BenatoCamilla NeroAlessia PiermatteiPier Paolo MattognoDiana GiannarelliGabriella FerrandinaAlessandro OliviAnna FagottiGiovanni ScambiaPublished in: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (2024)
mutations might impact brain metastasis occurrence and lead to better outcomes. In a multimodal treatment, surgery seems to affect survival even in cases of extracranial disease. PARPi use should be considered as it seems to prolong survival if administered after brain metastasis.
Keyphrases
- brain metastases
- small cell lung cancer
- free survival
- white matter
- resting state
- minimally invasive
- risk assessment
- dna damage
- functional connectivity
- cerebral ischemia
- type diabetes
- coronary artery bypass
- metabolic syndrome
- oxidative stress
- skeletal muscle
- replacement therapy
- subarachnoid hemorrhage
- middle cerebral artery