Preclinical evaluation of the effects on the gastrointestinal tract of the antineoplastic drug vincristine repeatedly administered to rats.

L López-GómezS Díaz-RuanoR GirónA E López-PérezG VeraE Herradón PliegoV López-MirandaKulmira NurgaliM I Martín-FontellesJosé Antonio Uranga Ocio Raquel Abalo

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2018)

Vincristine alters gastrointestinal motility, peripheral sensitivity and mucosal architecture. Vincristine-induced neuropathy (somatic and enteric), intestinal mucosa damage and inflammatory infiltrations are relatively long-lasting.

Keyphrases

oxidative stress
diabetic rats
high glucose
drug induced
biofilm formation
cell therapy
stem cells
ulcerative colitis
emergency department
adverse drug
pseudomonas aeruginosa
staphylococcus aureus
cystic fibrosis
dna methylation
genome wide