Astragaloside IV (ASIV) Mediates Endothelial Progenitor Cell (EPC) Exosomal LINC01963 to Inhibit Pyroptosis and Oxidative Stress in High Glucose-impaired Endothelial Cells.

Wu XiongJian-da ZhouMei-Xin TanYu LiuYu YanHua-Juan LeiJia-Rui PengWei LiuPei TanXi Zhang

Published in: Current molecular medicine (2023)

EPCs exosomal LINC01963 play an inhibitory role in high glucose-induced pyroptosis and oxidative stress of HUVECs. This study provides new ideas and directions for treating hyperglycemia and researching exosomal lncRNAs.

Keyphrases

high glucose
endothelial cells
oxidative stress
diabetic rats
long non coding rna
cell proliferation
long noncoding rna
nlrp inflammasome
dna damage
vascular endothelial growth factor
ischemia reperfusion injury
induced apoptosis