SGLT2 inhibition restrains thyroid cancer growth via G1/S phase transition arrest and apoptosis mediated by DNA damage response signaling pathways.
Yan WangLongyan YangLin MaoLijie ZhangYingjun ZhuYongsong XuYanan ChengRongxin SunYuanyuan ZhangJing KeDong ZhaoPublished in: Cancer cell international (2022)
SGLT2 inhibition may limit glucose uptake resulting in energetic crisis, following oxidative stress mediated DNA damage and cell cycle arrest, which resulted to the increased cell apoptosis and decreased proliferation of thyroid cancer cells, suggesting a potential use for SGLT2 inhibitors as thyroid cancer therapeutics.
Keyphrases
- cell cycle arrest
- oxidative stress
- pi k akt
- dna damage
- dna damage response
- signaling pathway
- cell death
- dna repair
- cell proliferation
- induced apoptosis
- ischemia reperfusion injury
- small molecule
- public health
- diabetic rats
- cell cycle
- endoplasmic reticulum stress
- blood glucose
- climate change
- epithelial mesenchymal transition
- human health