Placentas from obese women showed a significantly higher risk of maternal and fetal vascular and inflammatory placental lesions, both in overall population and in the subgroup with uncomplicated pregnancies. The metabolic and inflammatory dysfunctions typical of obesity could have an impact on placental development and function, which could be a mediator of the detrimental effects of obesity on pregnancy outcome and on future health of the offspring.
Keyphrases
- weight loss
- metabolic syndrome
- insulin resistance
- pregnancy outcomes
- type diabetes
- high fat diet induced
- weight gain
- adipose tissue
- polycystic ovary syndrome
- high fat diet
- bariatric surgery
- oxidative stress
- healthcare
- public health
- preterm birth
- mental health
- neoadjuvant chemotherapy
- squamous cell carcinoma
- body mass index
- clinical trial
- urinary tract infection
- open label
- breast cancer risk
- cervical cancer screening