The non-antibiotic macrolide EM900 attenuates HDM and poly(I:C)-induced airway inflammation with inhibition of macrophages in a mouse model.
Hironori SadamatsuKoichiro TakahashiHiroki TashiroGo KatoYoshihiko NoguchiKeigo KurataSatoshi ŌmuraShinya KimuraToshiaki SunazukaNaoko Sueoka-AraganePublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2019)
HDM and poly(I:C)-induced airway inflammation is attenuated by EM900 with the inhibition of lung interstitial macrophages. Clinical use of EM900 is expected, because EM900 has inhibitory effects against airway inflammation without inducing bacterial drug resistance.