Sarco/endoplasmic reticulum Ca2+ -ATPase 2b mediates oxidation-induced endoplasmic reticulum stress to regulate neuropathic pain.

Shaoheng LiFang ZhaoQinglian TangChuchu XiJing HeYujing WangMichael Xi Zhu Zheng-Yu Cao

Published in: British journal of pharmacology (2021)

Our findings reveal a novel pathway centering around SERCA2b as the key molecule underlying the mechanism of development and maintenance of neuropathic pain, and SERCA2b activators have the potential for therapeutic treatment of neuropathic pain.

Keyphrases

neuropathic pain
endoplasmic reticulum
endoplasmic reticulum stress
spinal cord
spinal cord injury
induced apoptosis
diabetic rats
dna methylation
endothelial cells
human health
climate change
replacement therapy
electron transfer