Development and Initial Assessment of [ 18 F]OP-801: a Novel Hydroxyl Dendrimer PET Tracer for Preclinical Imaging of Innate Immune Activation in the Whole Body and Brain.

Mackenzie L CarlsonIsaac M JacksonE Carmen AzevedoSamantha T ReyesIsrat S AlamRowaid KellowJessa B CastilloSydney C NagyRishi SharmaMatthew BrewerJeffrey ClelandBin ShenMichelle L James

Published in: Molecular imaging and biology (2023)

F]OP-801 is a promising new PET tracer for sensitive and specific detection of activated macrophages and microglia that warrants further investigation.

Keyphrases

positron emission tomography
innate immune
pet imaging
computed tomography
pet ct
high resolution
white matter
resting state
inflammatory response
loop mediated isothermal amplification
cell therapy
functional connectivity
stem cells
cerebral ischemia
mass spectrometry
spinal cord
clinical evaluation