The clinical relevance of the Hippo pathway in pancreatic ductal adenocarcinoma.
Richard DrexlerMirco KüchlerKim C WagnerTim ReeseBernd FeyerabendMoritz KleineKarl J OldhaferPublished in: Journal of cancer research and clinical oncology (2020)
The Hippo pathway is inactive in metastasized patients releasing the pro-metastatic and proliferative potential of the pathway. Furthermore, our study underlines the prognostic relevance of the Hippo pathway as a shift in the balance towards the inactive pathway predicts an unfavorable OS and DFS.