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The clinical relevance of the Hippo pathway in pancreatic ductal adenocarcinoma.

Richard DrexlerMirco KüchlerKim C WagnerTim ReeseBernd FeyerabendMoritz KleineKarl J Oldhafer
Published in: Journal of cancer research and clinical oncology (2020)
The Hippo pathway is inactive in metastasized patients releasing the pro-metastatic and proliferative potential of the pathway. Furthermore, our study underlines the prognostic relevance of the Hippo pathway as a shift in the balance towards the inactive pathway predicts an unfavorable OS and DFS.
Keyphrases
  • squamous cell carcinoma
  • small cell lung cancer
  • ejection fraction
  • chronic kidney disease
  • prognostic factors
  • patient reported