Macrophage-Derived 25-Hydroxycholesterol Promotes Vascular Inflammation, Atherogenesis, and Lesion Remodeling.

Alberto Canfrán-DuqueNoemi RotllanXinbo ZhangIrene Andrés-Blasco Bonne M ThompsonJonathan SunNathan L PriceMarta Fernández-FuertesJoseph W FowlerDiego Gómez-CoronadoWilliam C Sessa Chiara Giannarelli Robert J SchneiderGeorge TellidesJeffrey G McDonaldCarlos Fernández-Hernando Yajaira Suárez

Published in: Circulation (2022)

Production of 25-HC by activated macrophages amplifies their inflammatory phenotype, thus promoting atherogenesis.

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