Serpin B9 controls tumor cell killing by CAR T cells.
Thomas KimmanAnne SlompAnne MartensSarah GrabherrShuang LiEline van DiestJan MeeldijkJürgen H E KuballMonique C MinnemaEric ElderingNiels BovenschenZsolt SebestyénVictor PeperzakPublished in: Journal for immunotherapy of cancer (2023)
Overall, the data indicate that serpin B9 is a resistance mediator for CAR T cell-mediated tumor cell killing that should be inhibited or bypassed to improve CAR T-cell responses.