The many faces of sickle cell disease in children: complications in the appendicular skeleton.
Marcela De La Hoz PoloVictoria E HudsonJohn AduSubarna ChakravortySaira HaquePublished in: Pediatric radiology (2024)
Sickle cell disease (SCD) is a hereditary red cell disorder with clinical manifestations secondary to sickling or crescent-shaped distortion of the red blood cells. Musculoskeletal complications of SCD are often the main causes for acute and chronic morbidities in children with manifestations including osteomyelitis, osteoporosis and osteonecrosis. This article aims to familiarise the paediatric radiologist with appendicular skeletal complications of SCD in the paediatric population and their imaging appearance.
Keyphrases
- sickle cell disease
- red blood cell
- risk factors
- young adults
- intensive care unit
- emergency department
- liver failure
- high resolution
- single cell
- cell therapy
- postmenopausal women
- mass spectrometry
- mesenchymal stem cells
- photodynamic therapy
- fluorescence imaging
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- bone marrow
- mechanical ventilation