The Herb-Drug Interaction of Clopidogrel and Xuesaitong Dispersible Tablet by Modulation of the Pharmacodynamics and Liver Carboxylesterase 1A Metabolism.

Shi-Tang MaGuoliang DaiXiaolin BiMeirong GongChenggui MiaoHao ChenLiangliang GaoWeiman ZhaoTianjun Liu Ningru Zhang

Published in: Evidence-based complementary and alternative medicine : eCAM (2018)

30-days dose of coadministration altered hepatic CES1A protein and resulted in reduced plasma levels of active CAMD. both the decreased CES1A mRNA expression and the inhibition on the protein were due to the combination of XST, which accordingly upregulated the pharmacokinetics of plasma active CAMD.

Keyphrases

protein protein
acute coronary syndrome
binding protein
emergency department
small molecule
antiplatelet therapy
coronary artery disease