Licorice metabolite 18β-glycyrrhetinic acid activates G-protein-gated inwardly rectifying K + channels.

I-Shan ChenJumpei YasudaTakuya NotomiTomoe Y Nakamura

Published in: British journal of pharmacology (2023)

GA acts as a novel GIRK inhibitor and 18β-GA acts as a novel GIRK activator. 18β-GA alters atrial function via activation of GIRK channels. This study elucidates the pharmacological activity of licorice ingredients and provides information for drug design.

Keyphrases

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atrial fibrillation
nuclear factor
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mitral valve
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