What makes the psychosis 'clinical high risk' state risky: psychosis itself or the co-presence of a non-psychotic disorder?
Laila HasmiLotta-Katrin PriesMargreet Ten HaveRon de GraafSaskia van DorsselaerMaarten BakGunter KenisAlexander RichardsBochao D LinMichael C O'DonovanJurjen J LuykxBart P F RuttenSinahin GuloksuzJim Van OsPublished in: Epidemiology and psychiatric sciences (2021)
The risk in 'clinical high risk' states is mediated not by attenuated psychosis per se but specifically the combination of attenuated psychosis and NPD. CHR-P/APS research should be reconceptualised from a focus on attenuated psychotic symptoms with exclusion of non-psychotic DSM-disorders, as the 'pure' representation of a supposedly homotypic psychosis risk state, towards a focus on poor-outcome NPDs, characterised by a degree of psychosis admixture, on the pathway to psychotic disorder outcomes.