Association of Baseline Tumor-Specific Neoantigens and CD8 + T-Cell Infiltration With Immune-Related Adverse Events Secondary to Immune Checkpoint Inhibitors.
Csaba KerepesiHassan Mohammed AbushukairBiagio RicciutiAmin H NassarElio AdibJoao M Victor AlessiFederica PecciMehrdad RakaeeMuhammad Zaki Hidayatullah FadlullahAnna-Mária TőkésScott J RodigMark M AwadAik Choon TanTibor BakacsAbdul Rafeh NaqashPublished in: JCO precision oncology (2024)
Our findings highlight a potential role for TIME features, specifically INDEL neoantigens and baseline-immune infiltration, in enabling optimal irAE risk stratification of patients.