The Impact of Cannabis Use on Cognition in People with HIV: Evidence of Function-Dependent Effects and Mechanisms from Clinical and Preclinical Studies.
Samantha M AyoubBreanna M HollowayAlannah H MirandaBenjamin Z RobertsJared W YoungArpi MinassianRonald J EllisPublished in: Current HIV/AIDS reports (2024)
Results revealed little evidence to support a harmful impact of cannabis use on cognition in HIV, with few eligible preclinical data existing. Furthermore, the beneficial/harmful effects of cannabis use observed on cognition were function-dependent and confounded by several factors (e.g., age, frequency of use). Results are discussed alongside potential mechanisms of cannabis effects on cognition in HIV (e.g., anti-inflammatory), and considerations are outlined for screening PWH that may benefit from cannabis interventions. We further highlight the value of accelerating research discoveries in this area by utilizing translatable cross-species tasks to facilitate comparisons across human and animal work.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- human immunodeficiency virus
- mild cognitive impairment
- hepatitis c virus
- hiv aids
- white matter
- men who have sex with men
- anti inflammatory
- endothelial cells
- physical activity
- working memory
- machine learning
- single cell
- mesenchymal stem cells
- climate change