Login / Signup

The Role of Krüppel-like Factors in Pancreatic Physiology and Pathophysiology.

Michael GiarrizzoJoseph F LaCombAgnieszka B Bialkowska
Published in: International journal of molecular sciences (2023)
Krüppel-like factors (KLFs) belong to the family of transcription factors with three highly conserved zinc finger domains in the C-terminus. They regulate homeostasis, development, and disease progression in many tissues. It has been shown that KLFs play an essential role in the endocrine and exocrine compartments of the pancreas. They are necessary to maintain glucose homeostasis and have been implicated in the development of diabetes. Furthermore, they can be a vital tool in enabling pancreas regeneration and disease modeling. Finally, the KLF family contains proteins that act as tumor suppressors and oncogenes. A subset of members has a biphasic function, being upregulated in the early stages of oncogenesis and stimulating its progression and downregulated in the late stages to allow for tumor dissemination. Here, we describe KLFs' function in pancreatic physiology and pathophysiology.
Keyphrases
  • transcription factor
  • stem cells
  • type diabetes
  • cardiovascular disease
  • glycemic control
  • skeletal muscle
  • blood glucose
  • wound healing
  • insulin resistance