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MicroRNAs Related to TACE Treatment Response: A Review of the Literature from a Radiological Point of View.

Alessandro Marco BozzatoPaola MartinganoRoberta Antea Pozzi MucelliMarco Francesco Maria CavallaroMatteo CesarottoCristina MarcelloClaudio TiribelliDevis PascutRiccardo PizzolatoFabio Pozzi MucelliMauro GiuffréLory Saveria CrocèMaria Assunta Cova
Published in: Diagnostics (Basel, Switzerland) (2022)
Hepatocellular Carcinoma (HCC) is the sixth most common cancer in the world. Patients with intermediate stage (Barcelona Clinic Liver Cancer, B stage) hepatocellular carcinoma (HCC) have been able to benefit from TACE (transarterial chemoembolization) as a treatment option. MicroRNAs (miRNAs), i.e., a subclass of non-coding RNAs (ncRNAs), participate in post-transcriptional gene regulation processes and miRNA dysfunction has been associated with apoptosis resistance, cellular proliferation, tumor genesis, and progression. Only a few studies have investigated the role of miRNAs as biomarkers predicting TACE treatment response in HCC. Here, we review the studies' characteristics from a radiological point of view, also correlating data with radiological images chosen from the cases of our institution.
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