MicroRNAs Related to TACE Treatment Response: A Review of the Literature from a Radiological Point of View.
Alessandro Marco BozzatoPaola MartinganoRoberta Antea Pozzi MucelliMarco Francesco Maria CavallaroMatteo CesarottoCristina MarcelloClaudio TiribelliDevis PascutRiccardo PizzolatoFabio Pozzi MucelliMauro GiuffréLory Saveria CrocèMaria Assunta CovaPublished in: Diagnostics (Basel, Switzerland) (2022)
Hepatocellular Carcinoma (HCC) is the sixth most common cancer in the world. Patients with intermediate stage (Barcelona Clinic Liver Cancer, B stage) hepatocellular carcinoma (HCC) have been able to benefit from TACE (transarterial chemoembolization) as a treatment option. MicroRNAs (miRNAs), i.e., a subclass of non-coding RNAs (ncRNAs), participate in post-transcriptional gene regulation processes and miRNA dysfunction has been associated with apoptosis resistance, cellular proliferation, tumor genesis, and progression. Only a few studies have investigated the role of miRNAs as biomarkers predicting TACE treatment response in HCC. Here, we review the studies' characteristics from a radiological point of view, also correlating data with radiological images chosen from the cases of our institution.
Keyphrases
- oxidative stress
- case control
- papillary thyroid
- radiofrequency ablation
- primary care
- endoplasmic reticulum stress
- gene expression
- signaling pathway
- electronic health record
- cell death
- squamous cell
- transcription factor
- squamous cell carcinoma
- machine learning
- cell proliferation
- combination therapy
- liver metastases
- high resolution
- childhood cancer