HIV-associated neurodegeneration and neuroimmunity: multivoxel MR spectroscopy study in drug-naïve and treated patients.
Jasmina M BobanDusko KozicVesna TurkulovJelena OstojicRobert SemnicDajana LendakSnezana BrkicPublished in: European radiology (2017)
• This is the first multivoxel human brain 3T MRS study in HIV. • All observed areas of the brain are affected by neurodegenerative process. • Cingulate gyrus and subcortical white matter are most vulnerable to HIV-induced neurodegeneration. • cART is effective in control of inflammation but ineffective in preventing neurodegeneration.
Keyphrases
- white matter
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- end stage renal disease
- men who have sex with men
- oxidative stress
- ejection fraction
- chronic kidney disease
- multiple sclerosis
- peritoneal dialysis
- magnetic resonance
- south africa
- magnetic resonance imaging
- computed tomography
- single molecule
- resting state
- high glucose
- patient reported
- endothelial cells
- contrast enhanced
- stress induced