In silico modeling the potential clinical effect of growth factor treatment on the metabolism of human nucleus pulposus cells.
Emily E McDonnellTara Ní NéillNiamh WilsonStacey L DarwishJoseph S ButlerConor Timothy BuckleyPublished in: JOR spine (2024)
Biological agents exhibit unique characteristics and features, demanding tailored development strategies and individualized assessments rather than a one-size-fits-all approach. Therefore, the journey to realizing the full potential of biological therapies is long and costly. Nonetheless, it holds the promise of revolutionizing spinal healthcare and improving the quality of life for patients suffering from discogenic back pain.
Keyphrases
- growth factor
- healthcare
- end stage renal disease
- induced apoptosis
- ejection fraction
- endothelial cells
- newly diagnosed
- chronic kidney disease
- spinal cord
- prognostic factors
- peritoneal dialysis
- cell cycle arrest
- smoking cessation
- patient reported outcomes
- signaling pathway
- endoplasmic reticulum stress
- cell proliferation