Exploring the Interaction between Fractional Exhaled Nitric Oxide and Biologic Treatment in Severe Asthma: A Systematic Review.
Tommaso PianigianiLorenzo AlderighiMartina MeocciMaddalena MessinaBeatrice PereaSimona LuzziLaura BergantiniMiriana D'AlessandroRosa Metella RefiniElena BargagliPaolo CameliPublished in: Antioxidants (Basel, Switzerland) (2023)
Higher baseline FeNO levels appear to be associated with a greater benefit in terms of clinical control and reduction of exacerbation rate, while FeNO dynamics during biologic treatment remains a largely unexplored issue since few studies have investigated it as a primary outcome. FeNO remains detectable during biologic treatment, but its potential utility as a biomarker of clinical control is still unclear and represents an interesting research area to be developed.