Ground-State Proton-Transfer (GSPT)-Assisted Enhanced Two-Photon Uncaging from a Binol-based AIE-Fluorogenic Phototrigger.

Biswajit Roy Samrat Roy Moumita KunduSomnath MajiBipul PalMahitosh MandalN D Pradeep Singh

Published in: Organic letters (2021)

We demonstrated for the first time without any chemical modification the two-photon absorption (TPA) cross-section can be enhanced and red-shifted to the near-infrared (NIR) region by the ground-state proton-transfer (GSPT) process. Using GSPT, we developed a simple binol-based aggregation-induced emission (AIE)-fluorogenic phototrigger having a large two-photon uncaging cross-section in the "phototherapeutic window". As a proof of concept, we showed our phototrigger for the release of two different anticancer drugs in the NIR region.

Keyphrases

living cells
fluorescent probe
electron transfer
photodynamic therapy
single molecule
monte carlo
fluorescence imaging
drug induced
solid state