Exercise training worsens cardiac performance in males but does not change ejection fraction and improves hypertrophy in females in a mouse model of metabolic syndrome.
Melinda E TóthMárta SárközyGergő SzűcsBrigitta DukayPetra HajduÁgnes ZvaraLászló G PuskásGábor J SzebeniZsófia RuppertCsaba CsonkaFerenc KovácsAndrás KristonPéter HorváthBence KőváriGábor CserniTamás CsontMiklós SánthaPublished in: Biology of sex differences (2022)
HFD/APOB-100 mice showed sex-specific cardiovascular responses to MetS and ET; however, left ventricular gene expressions were similar between the groups except for leptin receptor and several stress response-related genes.
Keyphrases
- ejection fraction
- left ventricular
- aortic stenosis
- mouse model
- metabolic syndrome
- high fat diet
- insulin resistance
- high fat diet induced
- hypertrophic cardiomyopathy
- skeletal muscle
- cardiac resynchronization therapy
- acute myocardial infarction
- copy number
- heart failure
- mitral valve
- left atrial
- genome wide
- uric acid
- genome wide identification
- transcatheter aortic valve replacement
- aortic valve
- coronary artery disease
- binding protein
- cardiovascular disease
- atrial fibrillation
- genome wide analysis