Pharmacological Inhibition of Epidermal Growth Factor Receptor Prevents Intracranial Aneurysm Rupture by Reducing Endoplasmic Reticulum Stress.
Taichi IshiguroHajime FurukawaKyle PolenYushiro TakeHiroki SatoDaisuke KudoJordan MorganHiroki UchikawaTakuma MaedaOscar CisnerosRedi RahmaniJinglu AiSatoru EguchiMichael T LawtonTomoki HashimotoPublished in: Hypertension (Dallas, Tex. : 1979) (2024)
Our data suggest that EGFR activation is an upstream event that contributes to aneurysm rupture via the induction of ER stress. Pharmacological inhibition of EGFR or downstream ER stress may be a promising therapeutic strategy for preventing aneurysm rupture and subarachnoid hemorrhage.
Keyphrases
- epidermal growth factor receptor
- subarachnoid hemorrhage
- endoplasmic reticulum stress
- coronary artery
- tyrosine kinase
- advanced non small cell lung cancer
- brain injury
- induced apoptosis
- cerebral ischemia
- abdominal aortic aneurysm
- small cell lung cancer
- electronic health record
- big data
- machine learning
- oxidative stress
- mouse model
- signaling pathway