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Diffusion and perfusion MRI may predict EGFR amplification and the TERT promoter mutation status of IDH-wildtype lower-grade gliomas.

Yae Won ParkSung Soo AhnChae Jung ParkKyunghwa HanEui Hyun KimSeok-Gu KangJong Hee ChangSe Hoon KimSeung-Koo Lee
Published in: European radiology (2020)
• EGFR amplification and TERTp mutation are key molecular markers that predict an aggressive clinical course of IDHwt LGGs. • EGFR-amplified tumors showed lower ADC values than EGFR-non-amplified tumors, suggesting higher cellularity. • TERTp mutant tumors showed a higher plasma volume fraction than TERTp wildtype tumors, suggesting higher vascular proliferation and tumor angiogenesis.
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