Natural history of nonhuman primates after oral exposure to Ebola virus variant Makona.

Our observations highlight the susceptibility of NHPs, and by extension, likely humans, to relatively low doses of EBOV via the oral route. As this route of infection is likely a common portal of entry for filoviruses during outbreaks, the data presented here add to our understanding of the pathogenesis and host-response to infection under conditions mimicking real-world scenarios.