Influence of allopurinol on thiopurine associated toxicity: A retrospective population-based cohort study.

Jeroen P A Houwen Antoine C G Egberts Anthonius de Boer Erik M van Maarseveen Roderick H J Houwen Arief Lalmohamed

Published in: British journal of clinical pharmacology (2020)

In thiopurine users, allopurinol is associated with a 58% reduced risk of hepatotoxicity. In addition, thiopurine persistence was prolonged by 2.1 years in allopurinol users. These data support the use of allopurinol in individuals requiring thiopurine therapy.

Keyphrases

big data
stem cells
machine learning
drug induced
mesenchymal stem cells