Long-term hypercaloric diet exacerbates metabolic liver disease in PNPLA3 I148M animals.

Huan SuMadhuri HaqueSvea BeckerKarolina EdlundJulia DudaQingbi WangJohanna ReißingHanns-Ulrich MarschallLena S CandelsMohamed MohamedWilhelm SjölandLijun LiaoStephan A DrexlerTill StrowigJörg RahnenführerJan G HengstlerMaximilian HattingChristian Trautwein

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

With long-term HFD feeding, mice with the PNPLA3 I148M genotype show exacerbated NAFLD. This finding is linked to PNPLA3 I148M-specific changes in microbiota composition and liver gene expression showing a stronger inflammatory response leading to enhanced liver fibrosis progression.

Keyphrases

liver fibrosis
gene expression
inflammatory response
dna methylation
high fat diet
physical activity
weight loss
lps induced
lipopolysaccharide induced
high fat diet induced
immune response
toll like receptor
type diabetes
insulin resistance