Intravascular molecular imaging: translating pathophysiology of atherosclerosis into human disease conditions.
Masaru SeguchiAlp AytekinTobias LenzPhilipp NicolGrace R KlostermanAlicia BeeleEmina SabicLéa UtschAseel AlyaqoobDimitris GorpasVasilis NtziachristosFarouc A JafferPhilipp RauschendorferMichael JonerPublished in: European heart journal. Cardiovascular Imaging (2022)
Progression of atherosclerotic plaque in coronary arteries is characterized by complex cellular and non-cellular molecular interactions. Within recent years, atherosclerosis has been recognized as inflammation-driven disease condition, where progressive stages are characterized by morphological changes in plaque composition but also relevant molecular processes resulting in increased plaque vulnerability. While existing intravascular imaging modalities are able to resolve key morphological features during plaque progression, they lack capability to characterize the molecular profile of advanced atherosclerotic plaque. Because hybrid imaging modalities may provide incremental information related to plaque biology, they are expected to provide synergistic effects in detecting high risk patients and lesions. The aim of this article is to review existing literature on intravascular molecular imaging approaches, and to provide clinically oriented proposals of their application. In addition, we assembled an overview of future developments in this field geared towards detection of patients at risk for cardiovascular events.
Keyphrases
- coronary artery disease
- cardiovascular events
- end stage renal disease
- coronary artery
- ejection fraction
- cardiovascular disease
- newly diagnosed
- chronic kidney disease
- endothelial cells
- multiple sclerosis
- systematic review
- heart failure
- oxidative stress
- type diabetes
- patient reported outcomes
- single molecule
- current status
- photodynamic therapy
- fluorescence imaging
- health information