In vivo assessment of black seed oil single dose on prednisolone pharmacokinetics.

Rana Abutaima Yousef Al-EbiniAhmad AlkofahiAnas Alshishani Samar ThiabKumarappan C AlagammaiMohammad Khalid

Published in: The Journal of pharmacy and pharmacology (2023)

Administration of BSO decreased prednisolone Cmax and AUC0-last in rats indicating that there is a herb-drug interaction; however, p-gp inhibition cannot be concluded. Patients relying on folk medicine in chronic illnesses treatment might need to avoid combining BSO with prednisolone.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
peritoneal dialysis
prognostic factors
emergency department
drug induced
combination therapy