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A distinct retinal pigment epithelial cell autofluorescence pattern in choroideremia predicts early involvement of overlying photoreceptors.

Marta StevanovicJasmina Cehajic KapetanovicJasleen Kaur JollyRobert E MacLaren
Published in: Acta ophthalmologica (2019)
Retinal pigment epithelium (RPE) changes correlate with the health of the overlying EZ in choroideremia. The smooth FAF region likely represents early stages of the disease, with most of the area containing preserved EZ, whereas the mottled zone indicates more advanced stages and has mostly disrupted EZ. Because of the clear relationship between FAF findings and EZ integrity, FAF imaging can be used to monitor disease progression and identify areas of preserved EZ that could be rescued by gene therapy.
Keyphrases
  • gene therapy
  • healthcare
  • public health
  • high resolution
  • risk assessment
  • functional connectivity
  • health promotion