Non-Viral Gene Delivery to Hepatocellular Carcinoma via Intra-Arterial Injection.

Hannah J VaughanCamila G ZamboniKathryn M LulyLing LiKathleen L GabrielsonLaboni F HassanNicholas P RadantPranshu BhardwajFlorin M SelaruMartin G Pomper Jordan J Green

Published in: International journal of nanomedicine (2023)

Hepatic artery injection is a promising delivery approach for PBAE NPs and demonstrates increased targeted transfection of HCC tumors compared to intravenous administration, and offers a potential alternative to standard chemotherapies and TACE. This work demonstrates proof of concept for administration of polymeric PBAE nanoparticles via intra-arterial injection for gene delivery in rats.

Keyphrases

ultrasound guided
cancer therapy
drug delivery
high dose
low dose
drug release
risk assessment