The efficacy and safety of direct oral anticoagulants versus vitamin K antagonists in patients with left-sided bioprosthetic heart valves and atrial fibrillation: a systematic review and meta-analysis.
Dong LiPeng ChangHongliang ZhangFeng BaiQiang WuPublished in: European journal of clinical pharmacology (2023)
Our meta-analysis demonstrated that in patients with AF and BHV, compared with VKAs, using DOACs was associated with reduced stroke and major bleeding events without an increase of all-cause mortality and any bleeding. In the population younger than 75 years old, DOAC might be more effective in preventing cardiogenic stroke.
Keyphrases
- atrial fibrillation
- direct oral anticoagulants
- systematic review
- aortic valve
- oral anticoagulants
- catheter ablation
- left atrial
- left atrial appendage
- aortic valve replacement
- heart failure
- mitral valve
- percutaneous coronary intervention
- transcatheter aortic valve replacement
- meta analyses
- venous thromboembolism
- transcatheter aortic valve implantation
- brain injury
- subarachnoid hemorrhage